原子間力顕微鏡(AFM)は、無機から有機材料、生体分子までの多岐に渡る試料表面をナノメータースケール分解能で可視化できる表面構造解析ツールとして発展してきた。高速AFMの開発は1993年頃から進められ、2001年に1フレーム80msで撮影できる装置が報告された後、2008年頃に現行性能の高速AFMが確立し、特に生体分子の機能動態観察に応用されてきた。近年、ユーザーと関連論文数が増加し、分子の構造イメージングだけでなく、プローブによる構造操作や局所力学特性の定量計測、力学特性のマッピングも可能になってきている。講演では、高速AFMによる生体/合成分子の一分子ダイナミクス計測への最近の応用研究や機能拡張に向けた技術開発について紹介したい。
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